Long-Term Outcomes in Anterior Cruciate Ligament Reconstruction: A Systematic Review of Patellar Tendon Versus Hamstring Autografts.

BACKGROUND: Much controversy still exists surrounding graft choice in anterior cruciate ligament (ACL) reconstruction. Over the past decade, an increase in comparative studies with longer follow-up has enhanced our understanding of current graft options and outcomes. PURPOSE: To describe the long-term comparative outcomes of ACL reconstruction with autograft bone-patellar tendon-bone (BPTB) versus autograft hamstring (HS) ACL reconstruction with regard to clinical and radiographic outcomes. STUDY DESIGN: Systematic review; Level of evidence, 2. METHODS: A search of the PubMed, MEDLINE, Cochrane, and Scopus databases was performed to identify studies in the English language with outcome data comparing ACL reconstruction utilizing autograft BPTB and autograft HS; only studies with a minimum 5-year follow-up were included. Outcome data included failure and complications, manual and instrumented laxity, patient-reported outcomes, and radiographic risk of osteoarthritis. RESULTS: Twelve studies with a total of 953 patients met the inclusion criteria. Of these studies, 8 were level 1 evidence and 2 were level 2. Mean follow-up was 8.96 years (range, 5-15.3 years). No differences in graft failure or manual or instrumented laxity were seen in any studies. Lower clinical outcomes scores and greater motion loss were seen in BPTB patients in 1 and 2 studies, respectively. Two of 4 studies reporting on anterior knee pain, and 3 of 7 that recorded kneeling pain found it more frequently among BPTB patients. One study found significantly increased reoperation rates in HS patients, while another found a similar result in BPTB, and 1 study reported a significant increase in contralateral ACL tears in BPTB patients. Three of 5 studies reporting on radiographic evidence of osteoarthritis noted significantly increased rates in BPTB patients. CONCLUSION: This systematic review comparing long-term outcomes after ACL reconstruction with either autograft BPTB or autograft HS suggests no significant differences in manual/instrumented laxity and graft failures between graft types. An increase in long-term anterior knee pain, kneeling pain, and higher rates of osteoarthritis were noted with BPTB graft use

Composition Mixing during Blue Straggler Formation and Evolution

We use smoothed-particle hydrodynamics to examine differences between direct collisions of single stars and binary star mergers in their roles as possible blue straggler star formation mechanisms. We find in all cases that core helium in the progenitor stars is largely retained in the core of the remnant, almost independent of the type of interaction or the central concentration of the progenitor stars. We have also modelled the subsequent evolution of the hydrostatic remnants, including mass loss and energy input from the hydrodynamical interaction. The combination of the hydrodynamical and hydrostatic models enables us to predict that little mixing will occur during the merger of two globular cluster stars of equal mass. In contrast to the results of Proctor Sills, Bailyn, & Demarque (1995), we find that neither completely mixed nor unmixed models can match the absolute colors of observed blue stragglers in NGC 6397 at all luminosity levels. We also find that the color distribution is probably the crucial test for explanations of BSS formation - if stellar collisions or mergers are the correct mechanisms, a large fraction of the lifetime of the straggler must be spent away from the main sequence. This constraint appears to rule out the possibility of completely mixed models. For NGC 6397, unmixed models predict blue straggler lifetimes ranging from about 0.1 to 4 Gyr, while completely mixed models predict a range from about 0.6 to 4 Gyr.Comment: AASTeX, 28 pg., accepted for ApJ, also available at http://ucowww.ucsc.edu/~erics/bspaper.htm

Population ecology and conservation of red-billed choughs in Scotland. Final report on Knowledge Transfer Project

This report summarises the results of a Knowledge Transfer Research Project that was undertaken by Dr Jane Reid (University of Aberdeen), Professor Pat Monaghan, (University of Glasgow), Dr Eric and Mrs Sue Bignal (Scottish Chough Study Group) and Dr Davy McCracken (Scottish Agricultural College). Dr Maria Bogdanova was employed as the postdoctoral research assistant on the project. The work was carried out in partnership with Scottish Natural Heritage (SNH) and the Royal Society for the Protection of Birds (RSPB). Funding was provided by a Knowledge Transfer Grant from the Natural Environment Research Council (NERC, PIs P. Monaghan & J. Reid), with matching partnership funding and in-kind support from SNH and RSPB. The overall aims of the project were to develop the scientific understanding of the population ecology of choughs on Islay, and to use this understanding to inform the development of appropriate conservation strategies and policies. The project built on existing long-term research on Islay’s choughs. It involved further analysis of long-term data, plus two years of intensive fieldwork designed to answer specific questions. The work aimed primarily to understand the ecology of choughs in their sub-adult years (ie, from fledging to breeding age). Survival from fledging to breeding is a key factor in causing population change. However, relatively little was previously known about the behaviour and ecology of choughs during this time. This report provides an overview of the results of the scientific study and focuses on presenting the scientific evidence on which resulting recommendations for chough conservation management on Islay are based. The report is written with the intention of presenting the results of the data analyses, and the rationale underlying those analyses, in a way that is accessible to non-specialists. Further details of analyses and technicalities are provided in published, peer-reviewed papers and/or are available on request. The report provides information that will be of use to policy makers and conservation practitioners, and also highlights topics where further research is required before informed management decisions can be taken

Within-year and among-year variation in impacts of targeted conservation management on juvenile survival in a threatened population

Acknowledgements We thank all Islay landowners and farmers who allowed access to nest sites and supported supplementary feeding, especially Donald Jones and Robert and Tom Epps, and everyone who contributed to fieldwork and data collection. We thank NatureScot for funding supplementary feeding, led by Rae McKenzie, Jess Shaw and Des Thompson, and Royal Society for the Protection of Birds for logistic support. This work was supported by a Natural Environment Research Council iCASE studentship (NE/P009719/1) with NatureScot, and the Scottish Government’s 2011-2016 and 2016-2021 Strategic Research Programmes. Open access via Wiley agreement.Peer reviewedPublisher PD

Integrating advances in population and evolutionary ecology with conservation strategy through long-term studies of red-billed choughs

Acknowledgements The long-term study could not have been achieved without long-term support from numerous people, including Islay farmers and land-owners who facilitated access to nest sites and observation locations; all current and previous members of the Scottish Chough Forum; and NatureScot and RSPB (summarised in Appendix S2). We particularly thank Rae McKenzie of NatureScot, without whose enthusiasm and willingness to engage with apparently abstract ideas we would likely never have got beyond phase 1. Aspects of the work were funded by Natural Environment Research Council, NatureScot, University of Aberdeen, University of Glasgow, RSPB, Scottish Government’s Strategic Research Programme, Scotland’s Rural College, Killam Trusts and the Royal Society (details in Appendix S2). We thank David Jardine for his valuable contributions, and Rae McKenzie, Jess Shaw and Morven Laurie (NatureScot), and Jen Smart, Gillian Gilbert, Jack Fleming and Paul Walton (RSPB) for commenting on a manuscript draft.Peer reviewedPublisher PD

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

BACKGROUND: Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-aspartate glutamatergic receptors (NMDAR). At the molecular level, it has been proposed that the pro-neurotoxicity mediated by tPA might occur through extrasynaptic NMDAR containing the GluN2D subunit. Thus, selective antagonists targeting tPA/GluN2D-containing NMDAR signaling would be of interest to prevent noxious effects of tPA. RESULTS: Here, we compared three putative antagonists of GluN2D-containing NMDAR and we showed that the new compound UBP145 ((2R*,3S*)-1-(9-bromophenan-threne-3-carbonyl)piperazine-2,3-dicarboxylic acid) is far more selective for GluN2D subunits than memantine and PPDA (phenanthrene derivative (2S*, 3R*)-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid). Indeed, in vitro, in contrast to the two other compounds, UBP145 prevented NMDA toxicity only in neurons expressing GluN2D (ie, in cortical but not hippocampal neurons). Furthermore, in cultured cortical neurons, UBP145 fully prevented the pro-excitotoxic effect of tPA. In vivo, we showed that UBP145 potently prevented the noxious action of exogenous tPA on excitotoxic damages. Moreover, in a thrombotic stroke model in mice, administration of UBP145 prevented the deleterious effect of late thrombolysis by tPA. CONCLUSIONS: In conclusion, tPA exerts noxious effects on neurons by acting on GluN2D-containing NMDAR and pharmacological antagonists of GluN2D-containing NMDAR could be used to prevent the ability of tPA to promote neurotoxicity

The Scottish economy [September 1989]

[Abstract unavailable

Static and Dynamic Estimates of CO2 Storage Capacity in Two Saline Formations in the UK

TesisLIMAEscuela Profesional de ContabilidadT02326TPC 2 G15 2017FinanzasEl objetivo de la investigación fue determinar la relación del estado de flujos de efectivo y la solvencia de las empresas comercializadoras en el Perú en los periodos 2010 al 2015. También determinamos la relación de la actividad de operación, inversión y financiamiento con el endeudamiento patrimonial, el endeudamiento del activo total y la cobertura de gastos financieros. Aplicamos el análisis descriptivo – correlacional y el diseño no experimental de corte transversal en la data de empresas comerciales que informan a la Superintendencia de Mercado de Valores (SMV) en los periodos trimestrales del año 2010 - 2015. La actividad de operación, inversión y financiamiento se ha utilizado como una medida del Estado de Flujos de Efectivo, mientras que el endeudamiento patrimonial, el endeudamiento del activo total y la cobertura de gastos financieros obtenidos se utilizan como un indicador de la solvencia de una empresa. Los resultados revelan cuanto mayor sea el flujo obtenido del ejercicio anterior, mayor será la confianza de los bancos en la empresa y, consecuentemente, mayor será la posibilidad de endeudarse frente a terceros y mayor será el acceso a la financiación con terceros, así mismo; cuando el endeudamiento patrimonial y el endeudamiento del activo total es menor, mayor serán las actividades de inversión. Se recomienda a las empresas del sector comercialización del Perú usar como herramienta el EFE ya que esta herramienta podría ser usada como una oportunidad para obtener financiamiento externo y demostrar la solvencia de la empresa, por ello nos parece conveniente darle la importancia a este estado financiero